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UBAP2L Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q14157 |
| Other Accession | Q80X50, NP_001120792.1 |
| Reactivity | Human |
| Predicted | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 114535 Da |
| Antigen Region | 575-601 aa |
| Gene ID | 9898 |
|---|---|
| Other Names | Ubiquitin-associated protein 2-like, Protein NICE-4, UBAP2L, KIAA0144, NICE4 |
| Target/Specificity | This UBAP2L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 575-601 amino acids from the Central region of human UBAP2L. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | UBAP2L Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | UBAP2L (HGNC:29877) |
|---|---|
| Synonyms | KIAA0144, NICE4 |
| Function | Recruits the ubiquitination machinery to RNA polymerase II for polyubiquitination, removal and degradation, when the transcription-coupled nucleotide excision repair (TC-NER) machinery fails to resolve DNA damage (PubMed:35633597). Plays an important role in the activity of long-term repopulating hematopoietic stem cells (LT- HSCs) (By similarity). Is a regulator of stress granule assembly, required for their efficient formation (PubMed:29395067, PubMed:35977029). Required for proper brain development and neocortex lamination (By similarity). |
| Cellular Location | Nucleus. Chromosome. Cytoplasm Cytoplasm, Stress granule Note=Associates with nuclear chromatin. |
| Tissue Location | Ubiquitous.. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
UBAP2L contains 1 UBA domain and has 3 named isoforms. UBA domains are a commonly occurring sequence motif of approximately 45 amino acid residues that are found in diverse proteins involved in the ubiquitin/proteasome pathway, DNA excision-repair, and cell signalling via protein kinases. The function of this protein is not known.
References
Ichikawa, S., et al. J. Bone Miner. Res. 25(8):1821-1829(2010)
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Wang, Y.L., et al. J. Biol. Chem. 283(49):33808-33815(2008)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Beausoleil, S.A., et al. Nat. Biotechnol. 24(10):1285-1292(2006)
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