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ARPC2 Antibody (C-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - ARPC2 Antibody (C-term) AP18993b
    ARPC2 Antibody (C-term) (Cat. #AP18993b) western blot analysis in WiDr cell line lysates (35ug/lane).This demonstrates the ARPC2 antibody detected the ARPC2 protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession O15144
Other Accession P85970, Q9CVB6, Q3MHR7, NP_690601.1, Q0IH88, Q6IRB1
Reactivity Human
Predicted Xenopus, Bovine, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 34333 Da
Antigen Region 263-291 aa
Additional Information
Gene ID 10109
Other Names Actin-related protein 2/3 complex subunit 2, Arp2/3 complex 34 kDa subunit, p34-ARC, ARPC2, ARC34
Target/Specificity This ARPC2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 263-291 amino acids from the C-terminal region of human ARPC2.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsARPC2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ARPC2
Synonyms ARC34
Function Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9230079). Seems to contact the mother actin filament (PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947).
Cellular Location Cytoplasm, cytoskeleton. Cell projection. Synapse, synaptosome {ECO:0000250|UniProtKB:Q9CVB6}. Nucleus
Research Areas
Citations (0)
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Background

This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conserved through evolution. The exact role of the protein encoded by this gene, the p34 subunit, has yet to be determined. Two alternatively spliced variants have been characterized to date. Additional alternatively spliced variants have been described but their full length nature has not been determined. [provided by RefSeq].

References

Monfregola, J., et al. J. Biol. Chem. 285(22):16951-16957(2010)
Festen, E.A., et al. Am. J. Gastroenterol. 105(2):395-402(2010)
Franke, A., et al. Nat. Genet. 40(11):1319-1323(2008)
Xiao, F., et al. Brain Res. 1233, 168-175 (2008) :
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :

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$ 182.50
$ 70.00
Cat# AP18993b
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