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VAPB Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | O95292 |
| Other Accession | A2VDZ9, NP_004729.1 |
| Reactivity | Human |
| Predicted | Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 27228 Da |
| Antigen Region | 171-200 aa |
| Gene ID | 9217 |
|---|---|
| Other Names | Vesicle-associated membrane protein-associated protein B/C, VAMP-B/VAMP-C, VAMP-associated protein B/C, VAP-B/VAP-C, VAPB |
| Target/Specificity | This VAPB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 171-200 amino acids from the C-terminal region of human VAPB. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | VAPB Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | VAPB (HGNC:12649) |
|---|---|
| Function | Endoplasmic reticulum (ER)-anchored protein that mediates the formation of contact sites between the ER and endosomes via interaction with FFAT motif-containing proteins such as STARD3 or WDR44 (PubMed:32344433, PubMed:33124732). Interacts with STARD3 in a FFAT motif phosphorylation dependent manner (PubMed:33124732). Via interaction with WDR44 participates in neosynthesized protein export (PubMed:32344433). Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity (PubMed:16891305, PubMed:20940299). Involved in cellular calcium homeostasis regulation (PubMed:22131369). |
| Cellular Location | Endoplasmic reticulum membrane; Single-pass type IV membrane protein {ECO:0000250|UniProtKB:Q9P0L0}. Note=Present in mitochondria-associated membranes that are endoplasmic reticulum membrane regions closely apposed to the outer mitochondrial membrane |
| Tissue Location | Ubiquitous. Isoform 1 predominates. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a type IV membrane protein found in plasma and intracellular vesicle membranes. The encoded protein is found as a homodimer and as a heterodimer with VAPA. This protein also can interact with VAMP1 and VAMP2 and may be involved in vesicle trafficking.
References
Millecamps, S., et al. J. Med. Genet. 47(8):554-560(2010)
Langou, K., et al. J. Neurochem. 114(3):795-809(2010)
Tsai, C.P., et al. Neurobiol. Aging (2010) In press :
Nachreiner, T., et al. Biochem. Biophys. Res. Commun. 394(3):703-708(2010)
Funke, A.D., et al. Clin. Genet. 77(3):302-303(2010)
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