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ALDOB Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P05062 |
| Other Accession | P00884, P79226, Q91Y97, Q3T0S5, NP_000026.2, P52210 |
| Reactivity | Human |
| Predicted | Bovine, Mouse, Rabbit, Rat, Sheep |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 39473 Da |
| Antigen Region | 31-60 aa |
| Gene ID | 229 |
|---|---|
| Other Names | Fructose-bisphosphate aldolase B, Liver-type aldolase, ALDOB, ALDB |
| Target/Specificity | This ALDOB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 31-60 amino acids from the N-terminal region of human ALDOB. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ALDOB Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ALDOB {ECO:0000303|PubMed:15880727, ECO:0000312|HGNC:HGNC:417} |
|---|---|
| Function | Catalyzes the aldol cleavage of fructose 1,6-biphosphate to form two triosephosphates dihydroxyacetone phosphate and D- glyceraldehyde 3-phosphate in glycolysis as well as the reverse stereospecific aldol addition reaction in gluconeogenesis. In fructolysis, metabolizes fructose 1-phosphate derived from the phosphorylation of dietary fructose by fructokinase into dihydroxyacetone phosphate and D-glyceraldehyde (PubMed:10970798, PubMed:12205126, PubMed:20848650). Acts as an adapter independently of its enzymatic activity, exerts a tumor suppressor role by stabilizing the ternary complex with G6PD and TP53 to inhibit G6PD activity and keep oxidative pentose phosphate metabolism in check (PubMed:35122041). |
| Cellular Location | Cytoplasm, cytosol. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite |
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Provided below are standard protocols that you may find useful for product applications.
Background
Fructose-1,6-bisphosphate aldolase (EC 4.1.2.13) is a tetrameric glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Vertebrates have 3 aldolase isozymes which are distinguished by their electrophoretic and catalytic properties. Differences indicate that aldolases A, B, and C are distinct proteins, the products of a family of related 'housekeeping' genes exhibiting developmentally regulated expression of the different isozymes. The developing embryo produces aldolase A, which is produced in even greater amounts in adult muscle where it can be as much as 5% of total cellular protein. In adult liver, kidney and intestine, aldolase A expression is repressed and aldolase B is produced. In brain and other nervous tissue, aldolase A and C are expressed about equally. There is a high degree of homology between aldolase A and C. Defects in ALDOB cause hereditary fructose intolerance. [provided by RefSeq].
References
Bouteldja, N., et al. J. Inherit. Metab. Dis. 33(2):105-112(2010)
Coffee, E.M., et al. J. Inherit. Metab. Dis. 33(1):33-42(2010)
Segat, L., et al. J. Gastroenterol. Hepatol. 24(12):1840-1846(2009)
Davit-Spraul, A., et al. Mol. Genet. Metab. 94(4):443-447(2008)
Eriksson, A., et al. BMC Gastroenterol 8, 34 (2008) :
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