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STX4 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q12846 |
| Other Accession | Q08850, P70452, Q3SWZ3, NP_004595.2 |
| Reactivity | Human |
| Predicted | Bovine, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 34180 Da |
| Antigen Region | 132-160 aa |
| Gene ID | 6810 |
|---|---|
| Other Names | Syntaxin-4, Renal carcinoma antigen NY-REN-31, STX4, STX4A |
| Target/Specificity | This STX4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 132-160 amino acids from the Central region of human STX4. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | STX4 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | STX4 |
|---|---|
| Synonyms | STX4A |
| Function | Plasma membrane t-SNARE that mediates docking of transport vesicles (By similarity). Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane (By similarity). In neurons, recruited at neurite tips to membrane domains rich in the phospholipid 1-oleoyl-2-palmitoyl-PC (OPPC) which promotes neurite tip surface expression of the dopamine transporter SLC6A3/DAT by facilitating fusion of SLC6A3-containing transport vesicles with the plasma membrane (By similarity). Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes and in docking of synaptic vesicles at presynaptic active zones (By similarity). Required for normal hearing (PubMed:36355422). |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:Q08850}; Single-pass type IV membrane protein. Cell projection, neuron projection {ECO:0000250|UniProtKB:Q08850}. Cell projection, stereocilium {ECO:0000250|UniProtKB:P70452}. Note=Localizes to neurite tips in neuronal cells. {ECO:0000250|UniProtKB:Q08850} |
| Tissue Location | Expressed in neutrophils and neutrophil- differentiated HL-60 cells. Expression in neutrophils increases with differentiation. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes (By similarity). May also play a role in docking of synaptic vesicles at presynaptic active zones.
References
Evesson, F.J., et al. J. Biol. Chem. 285(37):28529-28539(2010)
Kennedy, M.J., et al. Cell 141(3):524-535(2010)
Brochetta, C., et al. Biochim. Biophys. Acta 1783(10):1781-1791(2008)
Cooper, G.M., et al. Blood 112(4):1022-1027(2008)
Low, S.H., et al. Mol. Biol. Cell 17(2):977-989(2006)
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