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TAPBP Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | O15533 |
| Other Accession | NP_003181.3 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 47571 Da |
| Antigen Region | 42-70 aa |
| Gene ID | 6892 |
|---|---|
| Other Names | Tapasin, TPN, TPSN, NGS-17, TAP-associated protein, TAP-binding protein, TAPBP, NGS17, TAPA |
| Target/Specificity | This TAPBP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 42-70 amino acids from the N-terminal region of human TAPBP. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | TAPBP Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TAPBP (HGNC:11566) |
|---|---|
| Synonyms | NGS17, TAPA |
| Function | Involved in the association of MHC class I with transporter associated with antigen processing (TAP) and in the assembly of MHC class I with peptide (peptide loading). |
| Cellular Location | Endoplasmic reticulum membrane; Single-pass type I membrane protein |
| Tissue Location | Neutrophils, mostly in fully differentiated cells. |
Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a transmembrane glycoprotein which mediates interaction between newly assembled major histocompatibility complex (MHC) class I molecules and the transporter associated with antigen processing (TAP), which is required for the transport of antigenic peptides across the endoplasmic reticulum membrane. This interaction is essential for optimal peptide loading on the MHC class I molecule. Up to four complexes of MHC class I and this protein may be bound to a single TAP molecule. This protein contains a C-terminal double-lysine motif (KKKAE) known to maintain membrane proteins in the endoplasmic reticulum. This gene lies within the major histocompatibility complex on chromosome 6. Alternative splicing results in three transcript variants encoding different isoforms.
References
Jiang, Q., et al. Tumour Biol. 31(5):451-459(2010)
Rizvi, S.M., et al. Traffic 11(3):332-347(2010)
Praveen, P.V., et al. Eur. J. Immunol. 40(1):214-224(2010)
Barcellos, L.F., et al. PLoS Genet. 5 (10), E1000696 (2009) :
Lindquist, J.A., et al. EMBO J. 17(8):2186-2195(1998)
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