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AEBP2 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q6ZN18 |
| Other Accession | A4FV57, NP_001107648.1 |
| Reactivity | Human |
| Predicted | Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 54467 Da |
| Antigen Region | 482-508 aa |
| Gene ID | 121536 |
|---|---|
| Other Names | Zinc finger protein AEBP2, Adipocyte enhancer-binding protein 2, AE-binding protein 2, AEBP2 |
| Target/Specificity | This AEBP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 482-508 amino acids from the C-terminal region of human AEBP2. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | AEBP2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | AEBP2 |
|---|---|
| Function | Acts as an accessory subunit for the core Polycomb repressive complex 2 (PRC2), which mediates histone H3K27 (H3K27me3) trimethylation on chromatin leading to transcriptional repression of the affected target gene (PubMed:15225548, PubMed:29499137, PubMed:31959557). Plays a role in nucleosome localization of the PRC2 complex (PubMed:29499137). |
| Cellular Location | Nucleus. Note=Localizes to chromatin as part of the PRC2 complex |
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Provided below are standard protocols that you may find useful for product applications.
Background
DNA-binding transcriptional repressor. AEBP2 may interact with and stimulate the activity of the PRC2 complex, which methylates 'Lys-9' and 'Lys-27' residues of histone H3.
References
Cao, R., et al. Mol. Cell 15(1):57-67(2004)
He, G.P., et al. J. Biol. Chem. 274(21):14678-14684(1999)
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