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GDE1 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, E |
|---|---|
| Primary Accession | Q9NZC3 |
| Other Accession | NP_057725.1 |
| Reactivity | Human, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 37718 Da |
| Antigen Region | 192-219 aa |
| Gene ID | 51573 |
|---|---|
| Other Names | Glycerophosphodiester phosphodiesterase 1, Membrane-interacting protein of RGS16, RGS16-interacting membrane protein, GDE1, MIR16 |
| Target/Specificity | This GDE1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 192-219 amino acids of human GDE1. |
| Dilution | WB~~1:1000 FC~~1:25 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | GDE1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GDE1 (HGNC:29644) |
|---|---|
| Function | Hydrolyzes the phosphodiester bond of glycerophosphodiesters such as glycerophosphoinositol (GroPIns) and glycerophosphoethanolamine (GroPEth), to yield a glycerol phosphate and an alcohol (By similarity). Hydrolyzes glycerophospho-N-acylethanolamines to N- acylethanolamines in the brain and participates in bioactive N- acylethanolamine biosynthesis such as anandamide (an endocannabinoid), N-palmitoylethanolamine (an anti-inflammatory), and N- oleoylethanolamine (an anorexic). In addition, has a lysophospholipase D activity by hydrolyzing N-acyl-lysoplasmenylethanolamine (N-acyl- lysoPlsEt) to N-acylethanolamine. However lysophospholipase D activity is lower than glycerophosphodiester phosphodiesterase activity (By similarity). Has little or no activity towards glycerophosphocholine (By similarity). |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:Q9JL55}; Multi-pass membrane protein. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q9JL55}; Multi-pass membrane protein. Note=Perinuclear vesicles and cell membrane {ECO:0000250|UniProtKB:Q9JL55} |
| Tissue Location | Widely expressed.. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
GDE1 has glycerophosphoinositol phosphodiesterase activity. Has little or no activity towards glycerophosphocholine. GDE1 activity can be modulated by G-protein signaling pathways (By similarity).
References
Zhang, X., et al. Cancer Res. 70(18):7176-7186(2010)
Corthals, S.L., et al. Leuk. Res. 34(5):677-681(2010)
Simon, G.M., et al. J. Biol. Chem. 283(14):9341-9349(2008)
Ma, J., et al. Atherosclerosis 191(1):63-72(2007)
Bachmann, A.S., et al. Gene 371(1):144-153(2006)
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