Mouse Slc10a2 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | P70172 |
Other Accession | NP_035518.1 |
Reactivity | Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 38134 Da |
Antigen Region | 39-65 aa |
Gene ID | 20494 |
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Other Names | Ileal sodium/bile acid cotransporter, Apical sodium-dependent bile acid transporter, ASBT, Ileal Na(+)/bile acid cotransporter, Ileal sodium-dependent bile acid transporter, IBAT, ISBT, Na(+)-dependent ileal bile acid transporter, Sodium/taurocholate cotransporting polypeptide, ileal, Solute carrier family 10 member 2, Slc10a2, Ntcp2 |
Target/Specificity | This Mouse Slc10a2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 39-65 amino acids from the N-terminal region of mouse Slc10a2. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | Mouse Slc10a2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | Slc10a2 |
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Synonyms | Ntcp2 |
Function | Plays a critical role in the sodium-dependent reabsorption of bile acids from the lumen of the small intestine (PubMed:10101301). Transports various bile acids, unconjugated or conjugated, such as cholate and taurocholate (PubMed:10101301). Also responsible for bile acid transport in the renal proximal tubules, a salvage mechanism that helps conserve bile acids. Works collaboratively with the Na(+)- taurocholate cotransporting polypeptide (NTCP), the organic solute transporter (OST), and the bile salt export pump (BSEP), to ensure efficacious biological recycling of bile acids during enterohepatic circulation (By similarity). |
Cellular Location | Membrane; Multi-pass membrane protein |
Tissue Location | Expressed in ileum.. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Slc10a2 plays a critical role in the sodium-dependent reabsorption of bile acids from the lumen of the small intestine. Plays a key role in cholesterol metabolism (By similarity).
References
Halpern, M.D., et al. Am. J. Physiol. Gastrointest. Liver Physiol. 299 (3), G623-G631 (2010) :
Festing, M.H., et al. Genesis 47(12):858-863(2009)
Cheng, X., et al. Drug Metab. Dispos. 37(11):2178-2185(2009)
Sarwar, Z., et al. Am. J. Physiol. Gastrointest. Liver Physiol. 297 (3), G532-G538 (2009) :
Saeki, T., et al. Biosci. Biotechnol. Biochem. 73(7):1535-1540(2009)
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