RRBP1 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
---|---|
Primary Accession | Q9P2E9 |
Other Accession | NP_004578.2 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 152456 Da |
Antigen Region | 1327-1355 aa |
Gene ID | 6238 |
---|---|
Other Names | Ribosome-binding protein 1, 180 kDa ribosome receptor homolog, RRp, ES/130-related protein, Ribosome receptor protein, RRBP1, KIAA1398 |
Target/Specificity | This RRBP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1327-1355 amino acids from the C-terminal region of human RRBP1. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | RRBP1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | RRBP1 |
---|---|
Synonyms | KIAA1398 |
Function | Acts as a ribosome receptor and mediates interaction between the ribosome and the endoplasmic reticulum membrane. |
Cellular Location | Endoplasmic reticulum membrane; Single-pass type III membrane protein |
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Provided below are standard protocols that you may find useful for product applications.
Background
Analysis of cDNA clones indicates that ribosome binding protein 1 may exist in different forms due to removal of tandem repeats, or partial intraexonic splicing of RRBP1. The form presented here is lacking the canine p180 ribosome-binding domain, NQGKKAEGAQ, which is tandemly repeated close to the N-terminus in other forms that haven't been fully characterized. RRBP1 has been excluded as a candidate gene in the cause of Alagille syndrome. Alternate splicing results in multiple transcript variants.
References
Ueno, T., et al. J. Biol. Chem. 285(39):29941-29950(2010)
Ueno, T., et al. Exp. Cell Res. 316(3):329-340(2010)
Krasnov, G.S., et al. Mol. Biol. (Mosk.) 43(2):348-356(2009)
Benyamini, P., et al. Mol. Biol. Cell 20(2):732-744(2009)
Bai, J.Z., et al. Cell Biol. Int. 32(5):473-483(2008)
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