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TRHR Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P34981 |
| Other Accession | Q01717, NP_003292.1 |
| Reactivity | Human |
| Predicted | Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 45085 Da |
| Antigen Region | 209-238 aa |
| Gene ID | 7201 |
|---|---|
| Other Names | Thyrotropin-releasing hormone receptor, TRH-R, Thyroliberin receptor, TRHR |
| Target/Specificity | This TRHR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 209-238 amino acids from the Central region of human TRHR. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | TRHR Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TRHR |
|---|---|
| Function | Receptor for thyrotropin-releasing hormone (TRH). Upon ligand binding, this G-protein-coupled receptor triggers activation of the phosphatidylinositol (IP3)-calcium-protein kinase C (PKC) pathway. |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Thyrotropin-releasing hormone (TRH; MIM 275120), a small neuropeptide, is widely distributed throughout the central and peripheral nervous system as well as in extraneural tissues. The peptide is synthesized in the hypothalamus and transported by the portal vascular system to the anterior pituitary where it acts on thyrotropic and lactotropic cells to promote secretion of TSH and prolactin, respectively. Thyrotropin-releasing hormone receptor is a G protein-coupled receptor that activates the inositol phospholipid-calcium-protein kinase C transduction pathway upon the binding of TRH. The TRHR gene is expressed in the thyrotrope cells of the anterior pituitary.
References
Gehret, A.U., et al. Biochem. J. 428(2):235-245(2010)
Gehret, A.U., et al. Mol. Pharmacol. 77(2):288-297(2010)
Zhu, C.C., et al. J. Biol. Chem. 277(31):28228-28237(2002)
Matre, V., et al. J. Neurochem. 72(1):40-50(1999)
Iwasaki, T., et al. J. Biol. Chem. 271(36):22183-22188(1996)
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