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PLLP Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9Y342 |
| Other Accession | P47987, Q9DCU2, NP_057077.1 |
| Reactivity | Human |
| Predicted | Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 19987 Da |
| Antigen Region | 1-30 aa |
| Gene ID | 51090 |
|---|---|
| Other Names | Plasmolipin, Plasma membrane proteolipid, PLLP, PMLP, TM4SF11 |
| Target/Specificity | This PLLP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human PLLP. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PLLP Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PLLP (HGNC:18553) |
|---|---|
| Synonyms | PMLP, TM4SF11 |
| Function | Main component of the myelin sheath that plays an important role in myelin membrane biogenesis and myelination (PubMed:26002055). Plays an essential function in apical endocytosis. Regulates epithelial development through the regulation of apical endocytosis (By similarity). Part of the intracellular machinery that mediates basolateral-to-apical transport of ICAM-1, an essential adhesion receptor in epithelial cells, from the subapical compartment in hepatic epithelial cells (PubMed:34999972). |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Myelin membrane; Multi-pass membrane protein. Apical cell membrane {ECO:0000250|UniProtKB:P47987}; Multi-pass membrane protein. Golgi apparatus. Note=In polarized cells, localized predominantly in the apical membrane (By similarity). Located in lipid raft (By similarity). Recycled between the plasma membrane and the Golgi complex (PubMed:26002055). PLLP is continuously recirculating in the cell (PubMed:26002055). {ECO:0000250|UniProtKB:A3KQ86, ECO:0000250|UniProtKB:P47987, ECO:0000269|PubMed:26002055} |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
PLLP appears to be involved in myelination. Could also participate in ion transport events as addition of plasmolipin to lipid bilayers induces the formation of ion channels, which are voltage-dependent and K(+)-selective (By similarity).
References
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Hamacher, M., et al. Mamm. Genome 12(12):933-937(2001)
Fischer, I., et al. J. Biol. Chem. 269(40):24912-24919(1994)
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