DRAM Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application ![]()
| WB, IHC-P, E |
---|---|
Primary Accession | Q8N682 |
Other Accession | Q9DC58 |
Reactivity | Human |
Predicted | Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 26253 Da |
Antigen Region | 27-56 aa |
Gene ID | 55332 |
---|---|
Other Names | DNA damage-regulated autophagy modulator protein 1, Damage-regulated autophagy modulator, DRAM1, DRAM |
Target/Specificity | This DRAM antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 27-56 amino acids from the N-terminal region of human DRAM. |
Dilution | WB~~1:1000 IHC-P~~1:10~50 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | DRAM Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | DRAM1 |
---|---|
Synonyms | DRAM |
Function | Lysosomal modulator of autophagy that plays a central role in p53/TP53-mediated apoptosis. Not involved in p73/TP73-mediated autophagy. |
Cellular Location | Lysosome membrane; Multi-pass membrane protein |

Provided below are standard protocols that you may find useful for product applications.
Background
This gene is regulated as part of the p53 tumor suppressor pathway. The gene encodes a lysosomal membrane protein that is required for the induction of autophagy by the pathway. Decreased transcriptional expression of this gene is associated with various tumors. This gene has a pseudogene on chromosome 4.
References
Kerley-Hamilton,J.S., Biochim. Biophys. Acta 1769 (4), 209-219 (2007) Crighton,D., Autophagy 3 (1), 72-74 (2007) Crighton,D., Cell 126 (1), 121-134 (2006) Green,D.R., Cell 126 (1), 30-32 (2006)

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