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FGF19 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | O95750 |
| Other Accession | NP_005108.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 24003 Da |
| Antigen Region | 175-202 aa |
| Gene ID | 9965 |
|---|---|
| Other Names | Fibroblast growth factor 19, FGF-19, FGF19 |
| Target/Specificity | This FGF19 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 175-202 amino acids from the C-terminal region of human FGF19. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | FGF19 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | FGF19 |
|---|---|
| Function | Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. Activity requires the presence of KLB and FGFR4. |
| Cellular Location | Secreted. |
| Tissue Location | Expressed in fetal brain, cartilage, retina, and adult gall bladder. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development cell growth, morphogenesis, tissue repair, tumor growth and invasion. This growth factor is a high affinity, heparin dependent ligand for FGFR4. Expression of this gene was detected only in fetal but not adult brain tissue. Synergistic interaction of the chick homolog and Wnt-8c has been shown to be required for initiation of inner ear development.
References
Rao, A.S., et al. Gastroenterology 139(5):1549-1558(2010)
Turnbull, C., et al. Nat. Genet. 42(6):504-507(2010)
Schreuder, T.C., et al. Am. J. Physiol. Gastrointest. Liver Physiol. 298 (3), G440-G445 (2010) :
Reiche, M., et al. Horm. Metab. Res. 42(3):178-181(2010)
Wu, X., et al. J. Biol. Chem. 285(8):5165-5170(2010)
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