MPHOSPH9 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
---|---|
Primary Accession | Q99550 |
Other Accession | NP_073619.2 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 133024 Da |
Antigen Region | 248-275 aa |
Gene ID | 10198 |
---|---|
Other Names | M-phase phosphoprotein 9, MPHOSPH9, MPP9 |
Target/Specificity | This MPHOSPH9 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 248-275 amino acids from the N-terminal region of human MPHOSPH9. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | MPHOSPH9 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | MPHOSPH9 |
---|---|
Synonyms | MPP9 |
Function | Negatively regulates cilia formation by recruiting the CP110- CEP97 complex (a negative regulator of ciliogenesis) at the distal end of the mother centriole in ciliary cells (PubMed:30375385). At the beginning of cilia formation, MPHOSPH9 undergoes TTBK2-mediated phosphorylation and degradation via the ubiquitin-proteasome system and removes itself and the CP110-CEP97 complex from the distal end of the mother centriole, which subsequently promotes cilia formation (PubMed:30375385). |
Cellular Location | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Golgi apparatus membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes to the distal and proximal end of centriole pairs in duplicated centrosomes. In ciliated cells, localizes to the distal and proximal end of daughter centriole and proximal of the mother centriole but not in the distal end of the mother centriole (PubMed:21399614). Recruited by KIF24 to the distal end of mother centriole where it forms a ring-like structure (PubMed:30375385). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
The function of this protein remains unknown.
References
Bailey, S.D., et al. Diabetes Care (2010) In press :
Goldstein, B.A., et al. BMC Genet. 11, 49 (2010) :
De Jager, P.L., et al. Lancet Neurol 8(12):1111-1119(2009)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
De Jager, P.L., et al. Nat. Genet. 41(7):776-782(2009)
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.