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GNMT Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q14749 |
| Other Accession | Q29513, Q29555, NP_061833.1 |
| Reactivity | Human |
| Predicted | Pig, Rabbit |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 32742 Da |
| Antigen Region | 78-106 aa |
| Gene ID | 27232 |
|---|---|
| Other Names | Glycine N-methyltransferase, GNMT |
| Target/Specificity | This GNMT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 78-106 amino acids from the Central region of human GNMT. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | GNMT Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GNMT (HGNC:4415) |
|---|---|
| Function | Catalyzes the methylation of glycine by using S- adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy), a reaction regulated by the binding of 5-methyltetrahydrofolate. Plays an important role in the regulation of methyl group metabolism by regulating the ratio between S-adenosyl-L-methionine and S-adenosyl-L- homocysteine. |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:P13255}. |
| Tissue Location | Expressed only in liver, pancreas, and prostate. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is an enzyme that catalyzes the conversion of S-adenosyl-L-methionine (along with glycine) to S-adenosyl-L-homocysteine and sarcosine. The encoded protein is found in the cytoplasm and acts as a homotetramer. Defects in this gene are a cause of GNMT deficiency (hypermethioninemia).
References
Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :
Lee, C.M., et al. Gene 443 (1-2), 151-157 (2009) :
Boyles, A.L., et al. Genet. Epidemiol. 33(3):247-255(2009)
Yen, C.H., et al. Toxicol. Appl. Pharmacol. 235(3):296-304(2009)
Franke, B., et al. Birth Defects Res. Part A Clin. Mol. Teratol. 85(3):216-226(2009)
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