NGFRAP1 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q00994 |
Other Accession | NP_996800.1 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 12959 Da |
Antigen Region | 14-42 aa |
Gene ID | 27018 |
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Other Names | Protein BEX3, Brain-expressed X-linked protein 3, Nerve growth factor receptor-associated protein 1, Ovarian granulosa cell 130 kDa protein HGR74, p75NTR-associated cell death executor, NGFRAP1, BEX3, DXS6984E, NADE |
Target/Specificity | This NGFRAP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 14-42 amino acids from the N-terminal region of human NGFRAP1. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | NGFRAP1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | BEX3 (HGNC:13388) |
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Synonyms | DXS6984E, NADE, NGFRAP1 |
Function | May be a signaling adapter molecule involved in NGFR/p75NTR- mediated apoptosis induced by NGF. Plays a role in zinc-triggered neuronal death. In absence of reductive stress, acts as a pseudosubstrate for the CRL2(FEM1B) complex: associates with FEM1B via zinc, thereby preventing association between FEM1B and its substrates. |
Cellular Location | Nucleus {ECO:0000250|UniProtKB:Q9WTZ9}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9WTZ9}. Note=Shuttles between the cytoplasm and the nucleus. Associates with replicating mitochondria. {ECO:0000250|UniProtKB:Q9WTZ9} |
Tissue Location | Found in ovarian granulosa cells, testis, prostate and seminal vesicle tissue. High levels also detected in liver |
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Provided below are standard protocols that you may find useful for product applications.
Background
NGFRAP1 may be a signaling adapter molecule involved in p75NTR-mediated apoptosis induced by NGF. Plays a role in zinc-triggered neuronal death (By similarity). May play an important role in the pathogenesis of neurogenetic diseases.
References
Yasui, S., et al. Mol. Cell. Neurosci. 35(1):100-108(2007)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Yu, Y., et al. Brain Res. 1100(1):13-20(2006)
Alvarez, E., et al. Gene 357(1):18-28(2005)
Ross, M.T., et al. Nature 434(7031):325-337(2005)
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