AGPAT9 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q53EU6 |
Other Accession | Q4V8J4, Q8C0N2, NP_116106.2 |
Reactivity | Human, Mouse |
Predicted | Rat |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 48705 Da |
Antigen Region | 194-222 aa |
Gene ID | 84803 |
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Other Names | Glycerol-3-phosphate acyltransferase 3, GPAT-3, 1-acyl-sn-glycerol-3-phosphate O-acyltransferase 10, AGPAT 10, 1-acyl-sn-glycerol-3-phosphate O-acyltransferase 9, 1-AGP acyltransferase 9, 1-AGPAT 9, Acyl-CoA:glycerol-3-phosphate acyltransferase 3, hGPAT3, Lung cancer metastasis-associated protein 1, Lysophosphatidic acid acyltransferase theta, LPAAT-theta, MAG-1, AGPAT9, GPAT3, MAG1 |
Target/Specificity | This AGPAT9 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 194-222 amino acids from the Central region of human AGPAT9. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | AGPAT9 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | GPAT3 (HGNC:28157) |
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Synonyms | AGPAT9, MAG1 |
Function | Converts glycerol-3-phosphate to 1-acyl-sn-glycerol-3- phosphate (lysophosphatidic acid or LPA) by incorporating an acyl moiety at the sn-1 position of the glycerol backbone (PubMed:17170135). Also converts LPA into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (PubMed:19318427). Protects cells against lipotoxicity (PubMed:30846318). |
Cellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein |
Tissue Location | Widely expressed. Expressed in liver, kidney, testis, brain, heart, skeletal muscle, thyroid, prostate, thymus and placenta. Also expressed lung and adipose tissue |
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Provided below are standard protocols that you may find useful for product applications.
Background
Glycerol-3-phosphate (G3P) acyltransferases (GPAT; EC 2.3.1.15), such as GPAM (MIM 602395) and GPAT3, catalyze the initial step of de novo triacylglycerol (TAG) synthesis by converting glycerol-3-phosphate (G3P) to lysophosphatidic acid (LPA) (Cao et al., 2006 [PubMed 17170135]).
References
Shan, D., et al. J. Lipid Res. 51(7):1971-1981(2010)
Cao, J., et al. Proc. Natl. Acad. Sci. U.S.A. 103(52):19695-19700(2006)
Tang, W., et al. J. Biochem. Mol. Biol. 39(5):626-635(2006)
Yamada, S., et al. Oncogene 23(35):5901-5911(2004)
Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)
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