DLEC1 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q9Y238 |
Other Accession | NP_031361 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 195684 Da |
Antigen Region | 879-908 aa |
Gene ID | 9940 |
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Other Names | Deleted in lung and esophageal cancer protein 1, Deleted in lung cancer protein 1, DLC-1, DLEC1 {ECO:0000312|EMBL:BAA776241} |
Target/Specificity | This DLEC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 879-908 amino acids from the Central region of human DLEC1. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | DLEC1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | DLEC1 {ECO:0000312|EMBL:BAA77624.1} |
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Function | Essential for spermatogenesis and male fertility (By similarity). May play an important role in sperm head and tail formation (By similarity). May act as a tumor suppressor by inhibiting cell proliferation. |
Cellular Location | Cytoplasm |
Tissue Location | Expressed in all tissues examined. Expression is highest in prostate and testis. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene contains 37 exons, spans approximately 59-kb, and is located in the 3p22-p21.3 chromosomal segment that is commonly deleted in various carcinomas. Several alternatively spliced transcripts have been observed that contain disrupted coding regions and likely encode nonfunctional proteins. Aberrant transcription of this gene may be involved in carcinogenesis of the lung, esophagus, and kidney.
References
Zhang, Q., et al. J. Urol. 184(2):731-737(2010)
Zhang, Y., et al. Clin Lung Cancer 11(4):264-270(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Al Sarakbi, W., et al. Anticancer Res. 30(4):1079-1082(2010)
Canova, C., et al. Cancer Res. 69(7):2956-2965(2009)
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