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CORO1B Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9BR76 |
| Other Accession | NP_001018080.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 54235 Da |
| Antigen Region | 383-409 aa |
| Gene ID | 57175 |
|---|---|
| Other Names | Coronin-1B, Coronin-2, CORO1B |
| Target/Specificity | This CORO1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 383-409 amino acids from the C-terminal region of human CORO1B. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CORO1B Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CORO1B |
|---|---|
| Function | Regulates leading edge dynamics and cell motility in fibroblasts. May be involved in cytokinesis and signal transduction (By similarity). |
| Cellular Location | Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, stress fiber. Note=Localized to the leading edge in fibroblasts, as well as weakly along actin stress fibers |
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Provided below are standard protocols that you may find useful for product applications.
Background
Members of the coronin family, such as CORO1B, are WD repeat-containing actin-binding proteins that regulate cell motility (Cai et al., 2005 [PubMed 16027158]).
References
Cai, L., et al. Cell 128(5):915-929(2007)
Cai, L., et al. J. Biol. Chem. 280(36):31913-31923(2005)
Cai, L., et al. J. Biol. Chem. 280(36):31913-31923(2005)
Parente, J.A. Jr., et al. J. Biol. Chem. 274(5):3017-3025(1999)
Okumura, M., et al. DNA Cell Biol. 17(9):779-787(1998)
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