SERTAD2 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q14140 |
Other Accession | Q9JJG5, NP_055570.1 |
Reactivity | Human |
Predicted | Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 33897 Da |
Antigen Region | 1-30 aa |
Gene ID | 9792 |
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Other Names | SERTA domain-containing protein 2, Transcriptional regulator interacting with the PHD-bromodomain 2, TRIP-Br2, SERTAD2, KIAA0127 |
Target/Specificity | This SERTAD2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human SERTAD2. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | SERTAD2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | SERTAD2 |
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Synonyms | KIAA0127, TRIPBR2 |
Function | Acts at E2F-responsive promoters as coregulator to integrate signals provided by PHD- and/or bromodomain-containing transcription factors. May act as coactivator as well as corepressor of E2F1-TFDP1 and E2F4-TFDP1 complexes on E2F consensus binding sites, which would activate or inhibit E2F-target genes expression. Modulates fat storage by down-regulating the expression of key genes involved in adipocyte lipolysis, thermogenesis and oxidative metabolism. |
Cellular Location | Nucleus. Cytoplasm. Note=Exported out of the nucleus via its NES in a XPO1-dependent manner. Once in the cytoplasm, is degraded by the proteasome |
Tissue Location | Expressed in adipose tissue. |
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Provided below are standard protocols that you may find useful for product applications.
Background
SERTAD2 acts at E2F-responsive promoters to integrate signals provided by PHD-and/or bromodomain-containing transcription factors (By similarity).
References
Rose, J. Phd, et al. Mol. Med. (2010) In press :
Cheong, J.K., et al. J Transl Med 7, 8 (2009) :
Cheong, J.K., et al. J. Biol. Chem. 283(17):11661-11676(2008)
Watanabe-Fukunaga, R., et al. Genes Cells 10(8):851-860(2005)
Hillier, L.W., et al. Nature 434(7034):724-731(2005)
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