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ADCY9 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | O60503 |
| Other Accession | NP_001107.2 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 150701 Da |
| Antigen Region | 1295-1323 aa |
| Gene ID | 115 |
|---|---|
| Other Names | Adenylate cyclase type 9, ATP pyrophosphate-lyase 9, Adenylate cyclase type IX, Adenylyl cyclase 9, ADCY9, KIAA0520 |
| Target/Specificity | This ADCY9 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1295-1323 amino acids from the C-terminal region of human ADCY9. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ADCY9 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ADCY9 |
|---|---|
| Synonyms | KIAA0520 |
| Function | Adenylyl cyclase that catalyzes the formation of the signaling molecule cAMP in response to activation of G protein-coupled receptors (PubMed:10987815, PubMed:12972952, PubMed:15879435, PubMed:9628827). Contributes to signaling cascades activated by CRH (corticotropin-releasing factor), corticosteroids and beta-adrenergic receptors (PubMed:9628827). |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
| Tissue Location | Detected in skeletal muscle, pancreas, lung, heart, kidney, liver, brain and placenta (PubMed:10987815, PubMed:9628827) Expressed in multiple cells of the lung, with expression highest in airway smooth muscle (PubMed:12972952). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Adenylate cyclase is a membrane bound enzyme that catalyses the formation of cyclic AMP from ATP. It is regulated by a family of G protein-coupled receptors, protein kinases, and calcium. The type 9 adenylyl cyclase is a widely distributed adenylyl cyclase, and it is stimulated by beta-adrenergic receptor activation but is insensitive to forskolin, calcium, and somatostatin.
References
Wojcik, C., et al. Am. J. Med. Genet. A 152A (2), 479-483 (2010) :
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Tantisira, K.G., et al. Hum. Mol. Genet. 14(12):1671-1677(2005)
Cumbay, M.G., et al. J. Pharmacol. Exp. Ther. 310(1):108-115(2004)
Small, K.M., et al. Pharmacogenetics 13(9):535-541(2003)
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