CALCRL Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application ![]()
| IHC-P-Leica, WB, E |
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Primary Accession | Q16602 |
Other Accession | Q8WN93, NP_005786.1 |
Reactivity | Human |
Predicted | Pig |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 52979 Da |
Antigen Region | 340-367 aa |
Gene ID | 10203 |
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Other Names | Calcitonin gene-related peptide type 1 receptor, CGRP type 1 receptor, Calcitonin receptor-like receptor, CALCRL, CGRPR |
Target/Specificity | This CALCRL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 340-367 amino acids from the Central region of human CALCRL. |
Dilution | WB~~1:2000 IHC-P-Leica~~1:500 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | CALCRL Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | CALCRL (HGNC:16709) |
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Synonyms | CGRPR |
Function | G protein-coupled receptor which specificity is determined by its interaction with receptor-activity-modifying proteins (RAMPs) (PubMed:32296767, PubMed:33602864, PubMed:8626685). Together with RAMP1, form the receptor complex for calcitonin-gene-related peptides CALCA/CGRP1 and CALCB/CGRP2 (PubMed:33602864). Together with RAMP2 or RAMP3, function as receptor complexes for adrenomedullin (ADM and ADM2) (PubMed:32296767, PubMed:9620797). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway (PubMed:32296767, PubMed:8626685). |
Cellular Location | Cell membrane; Multi-pass membrane protein |
Tissue Location | Predominantly expressed in the lung and heart. |

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Provided below are standard protocols that you may find useful for product applications.
Background
Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP2 or RAMP3 (By similarity). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Kuwasako, K., et al. Biochem. Biophys. Res. Commun. 392(3):380-385(2010)
Chang, C.L., et al. J. Biol. Chem. 285(2):1075-1080(2010)
Barwell, J., et al. Peptides 31(1):170-176(2010)
Yokoyama, K., et al. Nephron Clin Pract 115 (4), C237-C243 (2010) :

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