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TBR1 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q16650 |
| Other Accession | Q64336, NP_006584.1 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 74053 Da |
| Antigen Region | 52-80 aa |
| Gene ID | 10716 |
|---|---|
| Other Names | T-box brain protein 1, T-brain-1, TBR-1, TES-56, TBR1 |
| Target/Specificity | This TBR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 52-80 amino acids from the N-terminal region of human TBR1. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | TBR1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TBR1 |
|---|---|
| Function | Transcriptional repressor involved in multiple aspects of cortical development, including neuronal migration, laminar and areal identity, and axonal projection (PubMed:25232744, PubMed:30250039). As transcriptional repressor of FEZF2, it blocks the formation of the corticospinal (CS) tract from layer 6 projection neurons, thereby restricting the origin of CS axons specifically to layer 5 neurons (By similarity). |
| Cellular Location | Nucleus |
| Tissue Location | Brain. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene is a member of a conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. A similar protein has been disrupted in mice and shown to be critical for early cortical development, and causes loss of projection neurons in the olfactory bulbs and olfactory cortex. The C-terminal region this similar protein was found to be necessary and sufficient for association with the guanylate kinase domain of calcium/calmodulin-dependent serine protein kinase. [provided by RefSeq].
References
Hillier, L.W., et al. Nature 434(7034):724-731(2005)
Stefanovska, A.M., et al. Cancer Res. 61(22):8351-8352(2001)
Hsueh, Y.P., et al. Nature 404(6775):298-302(2000)
Bulfone, A., et al. Neuron 15(1):63-78(1995)
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