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CNDP1 Antibody (Center)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - CNDP1 Antibody (Center) AP17674c
    CNDP1 Antibody (Center) (Cat. #AP17674c) western blot analysis in A375 cell line lysates (35ug/lane).This demonstrates the CNDP1 antibody detected the CNDP1 protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q96KN2
Other Accession Q66HG3, Q8BUG2, NP_116038.4
Reactivity Human
Predicted Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 56692 Da
Antigen Region 142-170 aa
Additional Information
Gene ID 84735
Other Names Beta-Ala-His dipeptidase, CNDP dipeptidase 1, Carnosine dipeptidase 1, Glutamate carboxypeptidase-like protein 2, Serum carnosinase, CNDP1, CN1, CPGL2
Target/Specificity This CNDP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 142-170 amino acids from the Central region of human CNDP1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCNDP1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CNDP1 (HGNC:20675)
Synonyms CN1, CPGL2
Function Catalyzes the peptide bond hydrolysis in Xaa-His dipeptides, displaying the highest activity toward carnosine (beta-alanyl-L- histidine) and anserine (beta-alanyl-3-methyl-histidine).
Cellular Location Secreted.
Tissue Location Found in serum and adult nervous central system. Absent in serum from patients with homocarnosinosis
Research Areas
Citations (0)
citation

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Background

This gene encodes a member of the M20 metalloprotease family. The encoded protein is specifically expressed in the brain, is a homodimeric dipeptidase which was identified as human carnosinase. This gene contains trinucleotide (CTG) repeat length polymorphism in the coding region.

References

Alkhalaf, A., et al. Diabetologia (2010) In press :
Riedl, E., et al. Diabetes 59(8):1984-1990(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Mooyaart, A.L., et al. Diabetes 59(6):1555-1559(2010)
Kim, S., et al. Clin J Am Soc Nephrol 5(6):1072-1078(2010)

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$ 182.50
$ 70.00
Cat# AP17674c
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