RPIA Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | P49247 |
Other Accession | A2TLM1, P47968, Q3T186, NP_653164.2 |
Reactivity | Human |
Predicted | Bovine, Mouse, Pig |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 33269 Da |
Antigen Region | 181-207 aa |
Gene ID | 22934 |
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Other Names | Ribose-5-phosphate isomerase, Phosphoriboisomerase, RPIA, RPI |
Target/Specificity | This RPIA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 181-207 amino acids from the Central region of human RPIA. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | RPIA Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | RPIA (HGNC:10297) |
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Synonyms | RPI |
Function | Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate and participates in the first step of the non- oxidative branch of the pentose phosphate pathway. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is an enzyme, which catalyzes the reversible conversion between ribose-5-phosphate and ribulose-5-phosphate in the pentose-phosphate pathway. This gene is highly conserved in most organisms. The enzyme plays an essential role in the carbohydrate metabolism. Mutations in this gene cause ribose 5-phosphate isomerase deficiency. A pseudogene is found on chromosome 18.
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Berry, G.T. J. Inherit. Metab. Dis. 31 (6), 661 (2008) :
Wamelink, M.M., et al. J. Inherit. Metab. Dis. 31(6):703-717(2008)
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