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MTMR14 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q8NCE2 |
| Other Accession | Q8VEL2, NP_001070993.1, NP_001070994.1 |
| Reactivity | Human |
| Predicted | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 72203 Da |
| Antigen Region | 18-45 aa |
| Gene ID | 64419 |
|---|---|
| Other Names | Myotubularin-related protein 14, 313-, HCV NS5A-transactivated protein 4 splice variant A-binding protein 1, NS5ATP4ABP1, hJumpy, MTMR14, C3orf29 |
| Target/Specificity | This MTMR14 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 18-45 amino acids from the N-terminal region of human MTMR14. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | MTMR14 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MTMR14 (HGNC:26190) |
|---|---|
| Function | Lipid phosphatase that specifically dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate, generating phosphatidylinositol and phosphatidylinositol 5-phosphate. |
| Cellular Location | Cytoplasm. Note=Found in reticular structures and plasma membrane ruffles Concentrated near the nucleus. |
| Tissue Location | Expressed in various tissues, including heart, skeletal muscle, placenta, liver, lung, kidney and pancreas |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a myotubularin-related protein. The encoded protein is a phosphoinositide phosphatase that specifically dephosphorylates phosphatidylinositol 3,5-biphosphate and phosphatidylinositol 3-phosphate. Mutations in this gene are correlated with autosomal dominant centronuclear myopathy. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 18.
References
Gibbs, E.M., et al. Autophagy 6(6):819-820(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Vergne, I., et al. EMBO J. 28(15):2244-2258(2009)
Tosch, V., et al. Hum. Mol. Genet. 15(21):3098-3106(2006)
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