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GBP5 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q96PP8 |
| Other Accession | NP_443174.1, NP_001127958.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 66617 Da |
| Antigen Region | 140-167 aa |
| Gene ID | 115362 |
|---|---|
| Other Names | Guanylate-binding protein 5, GBP-TA antigen, GTP-binding protein 5, GBP-5, Guanine nucleotide-binding protein 5, GBP5 |
| Target/Specificity | This GBP5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 140-167 amino acids from the N-terminal region of human GBP5. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | GBP5 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GBP5 {ECO:0000303|PubMed:20180847, ECO:0000312|HGNC:HGNC:19895} |
|---|---|
| Function | Interferon (IFN)-inducible GTPase that plays important roles in innate immunity against a diverse range of bacterial, viral and protozoan pathogens (By similarity). Hydrolyzes GTP, but in contrast to other family members, does not produce GMP (PubMed:20180847). Following infection, recruited to the pathogen-containing vacuoles or vacuole- escaped bacteria and acts as a positive regulator of inflammasome assembly by promoting the release of inflammasome ligands from bacteria (By similarity). Acts by promoting lysis of pathogen-containing vacuoles, releasing pathogens into the cytosol (By similarity). Following pathogen release in the cytosol, promotes recruitment of proteins that mediate bacterial cytolysis: this liberates ligands that are detected by inflammasomes, such as lipopolysaccharide (LPS) that activates the non-canonical CASP4/CASP11 inflammasome or double- stranded DNA (dsDNA) that activates the AIM2 inflammasome (By similarity). As an activator of NLRP3 inflammasome assembly: promotes selective NLRP3 inflammasome assembly in response to microbial and soluble, but not crystalline, agents (PubMed:22461501). Independently of its GTPase activity, acts as an inhibitor of various viruses infectivity, such as HIV-1, Zika and influenza A viruses, by inhibiting FURIN-mediated maturation of viral envelope proteins (PubMed:26996307, PubMed:31091448). |
| Cellular Location | Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q8CFB4}; Lipid-anchor, GPI-like-anchor. Golgi apparatus membrane; Lipid-anchor. Cytoplasm |
| Tissue Location | Expressed in peripheral blood monocytes (at protein level). |
Research Areas
Citations (0)
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
Submit your citation using an Abcepta antibody to
info@abcepta.com, and receive a free "I Love Antibodies" mug.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
Belongs to the GBP family.
References
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Wehner, M., et al. FEBS J. 277(7):1597-1605(2010)
Ito, Y., et al. J. Infect. Dis. 197(5):663-666(2008)
Tripal, P., et al. J. Interferon Cytokine Res. 27(1):44-52(2007)
Fellenberg, F., et al. J. Invest. Dermatol. 122(6):1510-1517(2004)
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$ 385.00
$ 150.00
Cat# AP17262a
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