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TH1L Antibody (C-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - TH1L Antibody (C-term) AP17236b
    TH1L Antibody (C-term) (Cat. #AP17236b) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the TH1L antibody detected the TH1L protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q8IXH7
Other Accession A5GFY4, NP_945327.1
Reactivity Human
Predicted Pig
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 66247 Da
Antigen Region 548-576 aa
Additional Information
Gene ID 51497
Other Names Negative elongation factor C/D, NELF-C/D, TH1-like protein, NELFCD, NELFD, TH1, TH1L
Target/Specificity This TH1L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 548-576 amino acids from the C-terminal region of human TH1L.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTH1L Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NELFCD
Synonyms NELFD, TH1, TH1L
Function Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II (PubMed:12612062). The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex (PubMed:10199401).
Cellular Location Nucleus.
Tissue Location Widely expressed. Expressed in heart, brain, lung, placenta, liver, skeletal and cardiac muscle, adrenal, thyroid, kidney and pancreas.
Research Areas
Citations (0)
citation

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Background

The NELF complex of proteins interacts with the DSIF protein complex to repress transcriptional elongation by RNA polymerase II. The protein encoded by this gene is an essential part of the NELF complex. Alternative translation initiation site usage results in the formation of two isoforms with different N-termini.

References

Zou, W., et al. Cancer Sci. 101(10):2156-2162(2010)
Yang, Y., et al. J. Cell. Biochem. 109(5):1013-1024(2010)
Sun, J., et al. J. Biol. Chem. 285(9):6443-6452(2010)
Pal, P., et al. Croat. Med. J. 50(4):361-369(2009)
Cheng, C., et al. J. Biol. Chem. 284(13):8786-8796(2009)

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$ 182.50
$ 70.00
Cat# AP17236b
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