MYRIP Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q8NFW9 |
Other Accession | NP_056275.2 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 95706 Da |
Antigen Region | 659-686 aa |
Gene ID | 25924 |
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Other Names | Rab effector MyRIP, Exophilin-8, Myosin-VIIa- and Rab-interacting protein, Synaptotagmin-like protein lacking C2 domains C, SlaC2-c, Slp homolog lacking C2 domains c, MYRIP, SLAC2C |
Target/Specificity | This MYRIP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 659-686 amino acids from the C-terminal region of human MYRIP. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | MYRIP Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | MYRIP |
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Synonyms | SLAC2C |
Function | Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor proteins MYO5A and MYO7A. May link RAB27A-containing vesicles to actin filaments. Functions as a protein kinase A-anchoring protein (AKAP). May act as a scaffolding protein that links PKA to components of the exocytosis machinery, thus facilitating exocytosis, including insulin release (By similarity). |
Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:Q8K3I4}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q7TNY7} Cytoplasmic vesicle, secretory vesicle {ECO:0000250|UniProtKB:Q7TNY7} Note=In presynaptic and postsynaptic areas in photoreceptor cells and in the basal microvilli of retinal pigment epithelium cells. Associated with melanosomes. Colocalizes with actin filaments {ECO:0000250|UniProtKB:Q7TNY7} |
Tissue Location | Detected in brain, skin, heart, adrenal medulla, pancreas, intestine, liver, kidney, muscle and testis |
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Background
Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor proteins MYO5A and MYO7A. May link RAB27A-containing vesicles to actin filaments (By similarity).
References
Rose, J. Phd, et al. Mol. Med. (2010) In press :
Nightingale, T.D., et al. Blood 113(20):5010-5018(2009)
Hayasaka, S., et al. Asian J. Androl. 10(4):561-568(2008)
Goehring, A.S., et al. J. Biol. Chem. 282(45):33155-33167(2007)
Wu, C., et al. Proteomics 7(11):1775-1785(2007)
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