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Bmp1 Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - Bmp1 Antibody (C-term) AP1712a
    Bmp1 Antibody (R972) (Cat. #AP1712a) western blot analysis in mouse liver tissue lysates (35ug/lane).This demonstrates the Bmp1 antibody detected the Bmp1 protein (arrow).
    detail
  • IHC-P - Bmp1 Antibody (C-term) AP1712a
    Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
    detail
  • SPECIFICATION
  • CITATIONS: 1
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  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession P13497
Other Accession P98063
Reactivity Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 111249 Da
Antigen Region 957-986 aa
Additional Information
Gene ID 649
Other Names Bone morphogenetic protein 1, BMP-1, Mammalian tolloid protein, mTld, Procollagen C-proteinase, PCP, BMP1, PCOLC
Target/Specificity This Bmp1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 957-986 amino acids from the C-terminal region of human Bmp1.
Dilution WB~~1:1000
IHC-P~~1:50~100
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsBmp1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name BMP1
Synonyms PCOLC
Function Metalloprotease that plays key roles in regulating the formation of the extracellular matrix (ECM) via processing of various precursor proteins into mature functional enzymes or structural proteins (PubMed:33206546). Thereby participates in several developmental and physiological processes such as cartilage and bone formation, muscle growth and homeostasis, wound healing and tissue repair (PubMed:32636307, PubMed:33169406). Roles in ECM formation include cleavage of the C-terminal propeptides from procollagens such as procollagen I, II and III or the proteolytic activation of the enzyme lysyl oxidase LOX, necessary to formation of covalent cross- links in collagen and elastic fibers (PubMed:31152061, PubMed:33206546). Additional substrates include matricellular thrombospondin-1/THBS1 whose cleavage leads to cell adhesion disruption and TGF-beta activation (PubMed:32636307).
Cellular Location Golgi apparatus, trans-Golgi network. Secreted, extracellular space, extracellular matrix. Secreted. Note=Co-localizes with POSTN in the Golgi.
Tissue Location Ubiquitous.
Research Areas
Citations ( 0 )

Background

The BMP1 locus encodes a protein that is capable of inducing formation of cartilage in vivo. Although other bone morphogenetic proteins are members of the TGF-beta superfamily, BMP1 encodes a protein that is not closely related to other known growth factors. BMP1 protein and procollagen C proteinase (PCP), a secreted metalloprotease requiring calcium and needed for cartilage and bone formation, are identical. PCP or BMP1 protein cleaves the C-terminal propeptides of procollagen I, II, and III and its activity is increased by the procollagen C-endopeptidase enhancer protein. The BMP1 gene is expressed as alternatively spliced variants that share an N-terminal protease domain but differ in their C-terminal region.

References

Leighton, M., et al., J. Biol. Chem. 278(20):18478-18484 (2003).
Hartigan, N., et al., J. Biol. Chem. 278(20):18045-18049 (2003).
Garrigue-Antar, L., et al., J. Biol. Chem. 277(45):43327-43334 (2002).
Rattenholl, A., et al., J. Biol. Chem. 277(29):26372-26378 (2002).
Janitz, M., et al., J. Mol. Med. 76(2):141-146 (1998).

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$ 182.50
$ 70.00
Cat# AP1712a
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