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CRTAP Antibody (N-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - CRTAP Antibody (N-term) AP17060a
    CRTAP Antibody (N-term) (Cat. #AP17060a) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the CRTAP antibody detected the CRTAP protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession O75718
Other Accession NP_006362.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 46562 Da
Antigen Region 31-59 aa
Additional Information
Gene ID 10491
Other Names Cartilage-associated protein, CRTAP, CASP
Target/Specificity This CRTAP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 31-59 amino acids from the N-terminal region of human CRTAP.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCRTAP Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CRTAP
Synonyms CASP
Function Necessary for efficient 3-hydroxylation of fibrillar collagen prolyl residues.
Cellular Location Secreted, extracellular space, extracellular matrix
Tissue Location Found in articular chondrocytes. Expressed in a variety of tissues
Research Areas
Citations (0)
citation

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Background

The protein encoded by this gene is similar to the chicken and mouse CRTAP genes. The encoded protein is a scaffolding protein that may influence the activity of at least one member of the cytohesin/ARNO family in response to specific cellular stimuli. Defects in this gene are associated with osteogenesis imperfecta, a connective tissue disorder characterized by bone fragility and low bone mass.

References

Morello, R., et al. Curr Osteoporos Rep 8(2):77-83(2010)
Li, G.H., et al. Osteoporos Int 21(6):1009-1020(2010)
Fratzl-Zelman, N., et al. Bone 46(3):820-826(2010)
Chang, W., et al. Hum. Mol. Genet. 19(2):223-234(2010)
Marini, J.C., et al. Cell Tissue Res. 339(1):59-70(2010)

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$ 182.50
$ 70.00
Cat# AP17060a
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