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MTMR4 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9NYA4 |
| Other Accession | NP_004678.3 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 133353 Da |
| Antigen Region | 695-723 aa |
| Gene ID | 9110 |
|---|---|
| Other Names | Myotubularin-related protein 4, FYVE domain-containing dual specificity protein phosphatase 2, FYVE-DSP2, Zinc finger FYVE domain-containing protein 11, MTMR4, KIAA0647, ZFYVE11 |
| Target/Specificity | This MTMR4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 695-723 amino acids from the Central region of human MTMR4. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | MTMR4 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MTMR4 (HGNC:7452) |
|---|---|
| Function | Lipid phosphatase that specifically dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate, generating phosphatidylinositol and phosphatidylinositol 5-phosphate (PubMed:11302699, PubMed:16787938, PubMed:20736309, PubMed:27625994, PubMed:29962048, PubMed:30944173). Decreases the levels of phosphatidylinositol 3-phosphate, a phospholipid found in cell membranes where it acts as key regulator of both cell signaling and intracellular membrane traffic, in a subset of endosomal membranes to negatively regulate both endocytic recycling and trafficking and/or maturation of endosomes toward lysosomes (PubMed:16787938, PubMed:20736309, PubMed:29962048). Through phosphatidylinositol 3-phosphate turnover in phagosome membranes regulates phagocytosis and phagosome maturation (PubMed:31543504). By decreasing phosphatidylinositol 3-monophosphate (PI3P) levels in immune cells it can also regulate the innate immune response (PubMed:30944173). Beside its lipid phosphatase activity, can also function as a molecular adapter to regulate midbody abscission during mitotic cytokinesis (PubMed:25659891). Can also negatively regulate TGF-beta and BMP signaling through Smad proteins dephosphorylation and retention in endosomes (PubMed:20061380, PubMed:23150675). |
| Cellular Location | Early endosome membrane; Peripheral membrane protein. Recycling endosome membrane; Peripheral membrane protein. Late endosome membrane; Peripheral membrane protein. Cytoplasmic vesicle, phagosome membrane; Peripheral membrane protein |
| Tissue Location | Expressed in brain, heart, kidney, spleen, liver, colon, testis, muscle, placenta, thyroid gland, pancreas, ovary, prostate, skin, peripheral blood, and bone marrow |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Dephosphorylates proteins phosphorylated on Ser, Thr, and Tyr residues and low molecular weight phosphatase substrate para-nitrophenylphosphate. Phosphorylates phosphatidylinositol 3,4,5-trisphosphate (PIP3).
References
Yu, J., et al. J. Biol. Chem. 285(11):8454-8462(2010) Dolley, G., et al. Mol. Genet. Metab. 97(2):149-154(2009) Plant, P.J., et al. Biochem. J. 419(1):57-63(2009) Colland, F., et al. Genome Res. 14(7):1324-1332(2004) Zhao, R., et al. Exp. Cell Res. 265(2):329-338(2001)
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