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KIF5B Antibody (C-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - KIF5B Antibody (C-term) AP16898b
    KIF5B Antibody (C-term) (Cat. #AP16898b) western blot analysis in mouse cerebellum tissue lysates (35ug/lane).This demonstrates the KIF5B antibody detected the KIF5B protein (arrow).
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession P33176
Other Accession Q2PQA9, Q61768, NP_004512.1
Reactivity Human, Mouse
Predicted Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 109685 Da
Antigen Region 867-895 aa
Additional Information
Gene ID 3799
Other Names Kinesin-1 heavy chain, Conventional kinesin heavy chain, Ubiquitous kinesin heavy chain, UKHC, KIF5B, KNS, KNS1
Target/Specificity This KIF5B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 867-895 amino acids from the C-terminal region of human KIF5B.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsKIF5B Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KIF5B (HGNC:6324)
Synonyms KNS, KNS1
Function Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner (By similarity). Regulates centrosome and nuclear positioning during mitotic entry. During the G2 phase of the cell cycle in a BICD2- dependent manner, antagonizes dynein function and drives the separation of nuclei and centrosomes (PubMed:20386726). Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation (By similarity). Through binding with PLEKHM2 and ARL8B, directs lysosome movement toward microtubule plus ends (Probable). Involved in NK cell-mediated cytotoxicity. Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells (PubMed:24088571).
Cellular Location Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q2PQA9}. Cytolytic granule membrane. Lysosome membrane; Peripheral membrane protein; Cytoplasmic side Note=Uniformly distributed between soma and neurites in hippocampal neurons. {ECO:0000250|UniProtKB:Q2PQA9}
Research Areas
Citations (0)
citation

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Background

Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes (By similarity).

References

Seeger, M.A., et al. J. Biol. Chem. 285(11):8155-8162(2010)
Trejo, H.E., et al. FASEB J. 24(2):374-382(2010)
Morton, A.M., et al. Biochem. Biophys. Res. Commun. 391(1):388-393(2010)
Zadeh, A.D., et al. J. Physiol. (Lond.) 587 (PT 19), 4565-4574 (2009) :
Wong, Y.L., et al. Biophys. J. 96(7):2799-2807(2009)

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$ 182.50
$ 70.00
Cat# AP16898b
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