SDC4 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | P31431 |
Other Accession | NP_002990.2 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 21642 Da |
Antigen Region | 98-127 aa |
Gene ID | 6385 |
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Other Names | Syndecan-4, SYND4, Amphiglycan, Ryudocan core protein, SDC4 |
Target/Specificity | This SDC4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 98-127 amino acids from the Central region of human SDC4. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | SDC4 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | SDC4 (HGNC:10661) |
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Function | Cell surface proteoglycan which regulates exosome biogenesis in concert with SDCBP and PDCD6IP (PubMed:22660413). |
Cellular Location | [Isoform 1]: Membrane; Single-pass type I membrane protein. Secreted. Note=Shedding of the ectodomain produces a soluble form. |
Tissue Location | Detected in fibroblasts (at protein level) (PubMed:1500433, PubMed:36213313). Also expressed in epithelial cells (PubMed:1500433). |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan that functions as a receptor in intracellular signaling. The encoded protein is found as a homodimer and is a member of the syndecan proteoglycan family. This gene is found on chromosome 20, while a pseudogene has been found on chromosome 22.
References
Buhligen, J., et al. J. Cell. Physiol. 225(3):905-914(2010)
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Carvallo, L., et al. J. Biol. Chem. 285(38):29546-29555(2010)
Wang, Y., et al. J. Hum. Genet. 55(8):490-494(2010)
Hallberg, G., et al. Reprod. Biol. Endocrinol. 8, 35 (2010) :
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