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HECW2 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9P2P5 |
| Other Accession | Q6I6G8, NP_065811.1 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 175769 Da |
| Antigen Region | 848-876 aa |
| Gene ID | 57520 |
|---|---|
| Other Names | E3 ubiquitin-protein ligase HECW2, 632-, HECT, C2 and WW domain-containing protein 2, NEDD4-like E3 ubiquitin-protein ligase 2, HECW2, KIAA1301, NEDL2 |
| Target/Specificity | This HECW2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 848-876 amino acids from the Central region of human HECW2. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | HECW2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | HECW2 |
|---|---|
| Synonyms | KIAA1301, NEDL2 |
| Function | E3 ubiquitin-protein ligase that mediates ubiquitination of TP73. Acts to stabilize TP73 and enhance activation of transcription by TP73 (PubMed:12890487). Involved in the regulation of mitotic metaphase/anaphase transition (PubMed:24163370). |
| Cellular Location | Cytoplasm. Cytoplasm, cytoskeleton, spindle |
| Tissue Location | Predominantly expressed in adult brain, lung and heart. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
E3 ubiquitin-protein ligase that mediates ubiquitination of TP73. Acts to stabilize TP73 and enhance activation of transcription by TP73.
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Miyazaki, K., et al. Biochem. Biophys. Res. Commun. 308(1):106-113(2003)
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