SEL1L Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
---|---|
Primary Accession | Q9UBV2 |
Other Accession | NP_005056.3 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 88755 Da |
Antigen Region | 83-112 aa |
Gene ID | 6400 |
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Other Names | Protein sel-1 homolog 1, Suppressor of lin-12-like protein 1, Sel-1L, SEL1L, TSA305 |
Target/Specificity | This SEL1L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 83-112 amino acids from the N-terminal region of human SEL1L. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | SEL1L Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | SEL1L |
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Synonyms | TSA305 |
Function | Plays a role in the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins (PubMed:16186509, PubMed:29997207). Enhances SYVN1 stability. Plays a role in LPL maturation and secretion. Required for normal differentiation of the pancreas epithelium, and for normal exocrine function and survival of pancreatic cells. May play a role in Notch signaling. |
Cellular Location | Endoplasmic reticulum membrane; Single-pass type I membrane protein |
Tissue Location | Highly expressed in pancreas. |
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Provided below are standard protocols that you may find useful for product applications.
Background
SEL1L may play a role in Notch signaling (By similarity). May be involved in the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins.
References
Ban, H.J., et al. BMC Genet. 11, 26 (2010) :
Riemer, J., et al. Proc. Natl. Acad. Sci. U.S.A. 106(35):14831-14836(2009)
Cormier, J.H., et al. Mol. Cell 34(5):627-633(2009)
Oresic, K., et al. Biosci. Rep. 29(3):173-181(2009)
Cattaneo, M., et al. J. Biol. Chem. 284(17):11405-11415(2009)
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