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CLPTM1L Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q96KA5 |
| Other Accession | NP_110409.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 62229 Da |
| Antigen Region | 370-399 aa |
| Gene ID | 81037 |
|---|---|
| Other Names | Cleft lip and palate transmembrane protein 1-like protein, CLPTM1-like protein, Cisplatin resistance-related protein 9, CRR9p, CLPTM1L, CRR9 |
| Target/Specificity | This CLPTM1L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 370-399 amino acids from the C-terminal region of human CLPTM1L. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CLPTM1L Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CLPTM1L |
|---|---|
| Synonyms | CRR9 |
| Function | Scramblase that mediates the translocation of glucosaminylphosphatidylinositol (alpha-D-GlcN-(1-6)-(1,2-diacyl-sn- glycero-3-phospho)-1D-myo-inositol, GlcN-PI) across the endoplasmic reticulum (ER) membrane, from the cytosolic leaflet to the luminal leaflet of the ER membrane, where it participates in the biosynthesis of glycosylphosphatidylinositol (GPI) (PubMed:35344438). GPI is a lipid glycoconjugate involved in post-translational modification of proteins (PubMed:35344438). Can also translocate 1,2-diacyl-sn-glycero-3- phospho-(1D-myo-inositol) (phosphatidylinositol or PI), as well as several other phospholipids (1,2-diacyl-sn-glycero-3-phosphocholine, 1,2-diacyl-sn-glycero-3-phosphoethanolamine), and N- acetylglucosaminylphosphatidylinositol (GlcNAc-PI) in vitro (PubMed:35344438). |
| Cellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein |
| Tissue Location | Ubiquitously expressed. |
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Provided below are standard protocols that you may find useful for product applications.
Background
CLPTM1L enhances cisplatin-mediated apoptosis, when overexpressed.
References
Liu, Z., et al. Carcinogenesis 31(11):1977-1981(2010) Hsiung, C.A., et al. PLoS Genet. 6 (8) (2010) : Truong, T., et al. J. Natl. Cancer Inst. 102(13):959-971(2010) Pooley, K.A., et al. Cancer Epidemiol. Biomarkers Prev. 19(7):1862-1865(2010) Turnbull, C., et al. Nat. Genet. 42(7):604-607(2010)
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