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IGBP1 Antibody (Center)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - IGBP1 Antibody (Center) AP16231C
    IGBP1 Antibody (Center) (Cat. #AP16231c) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the IGBP1 antibody detected the IGBP1 protein (arrow).
    detail
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession P78318
Other Accession NP_001542.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 39222 Da
Antigen Region 142-171 aa
Additional Information
Gene ID 3476
Other Names Immunoglobulin-binding protein 1, B-cell signal transduction molecule alpha 4, Protein alpha-4, CD79a-binding protein 1, Protein phosphatase 2/4/6 regulatory subunit, Renal carcinoma antigen NY-REN-16, IGBP1, IBP1
Target/Specificity This IGBP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 142-171 amino acids from the Central region of human IGBP1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsIGBP1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name IGBP1
Synonyms IBP1
Function Associated to surface IgM-receptor; may be involved in signal transduction. Involved in regulation of the catalytic activity of the phosphatases PP2A, PP4 and PP6 by protecting their partially folded catalytic subunits from degradative polyubiquitination until they associate with regulatory subunits.
Cellular Location Cytoplasm.
Tissue Location Ubiquitously expressed with highest levels in heart, skeletal muscle and pancreas
Research Areas
Citations (0)
citation

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Background

The proliferation and differentiation of B cells is dependent upon a B-cell antigen receptor (BCR) complex. Binding of antigens to specific B-cell receptors results in a tyrosine phosphorylation reaction through the BCR complex and leads to multiple signal transduction pathways.

References

McDonald, W.J., et al. J. Cell. Biochem. 110(5):1123-1129(2010)
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Fielhaber, J.A., et al. J. Biol. Chem. 284(36):24341-24353(2009)
Chen, G.I., et al. J. Biol. Chem. 283(43):29273-29284(2008)
Aranda-Orgilles, B., et al. PLoS ONE 3 (10), E3507 (2008) :

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$ 182.50
$ 70.00
Cat# AP16231C
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