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KRT28 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q7Z3Y7 |
| Other Accession | NP_853513.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 50567 Da |
| Antigen Region | 432-460 aa |
| Gene ID | 162605 |
|---|---|
| Other Names | Keratin, type I cytoskeletal 28, Cytokeratin-28, CK-28, Keratin-25D, K25D, Keratin-28, K28, Type I inner root sheath-specific keratin-K25irs4, KRT28 (HGNC:30842) |
| Target/Specificity | This KRT28 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 432-460 amino acids from the C-terminal region of human KRT28. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | KRT28 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | KRT28 (HGNC:30842) |
|---|---|
| Function | Essential for the proper assembly of types I and II keratin protein complexes and the formation of keratin intermediate filaments in the inner root sheath (irs). |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:A6BLY7}. |
| Tissue Location | Strongly expressed in skin and scalp, and weak expression observed in thymus. In the hair follicle, expressed in Henle layer, Huxley layer and in the irs cuticle. Expression extends from the bulb region up to the point of differentiation into the three layers Also present in the medulla of beard hair (at protein level) |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the type I (acidic) keratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. The type I keratin genes are clustered in a region of chromosome 17q12-q21.
References
Schweizer, J., et al. J. Cell Biol. 174(2):169-174(2006)
Rogers, M.A., et al. Differentiation 72 (9-10), 527-540 (2004) :
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