P2RX2 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q9UBL9 |
Other Accession | NP_057402.1, NP_777362.1, NP_733783.1 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 51754 Da |
Antigen Region | 81-109 aa |
Gene ID | 22953 |
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Other Names | P2X purinoceptor 2, P2X2, ATP receptor, Purinergic receptor, P2RX2, P2X2 |
Target/Specificity | This P2RX2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 81-109 amino acids from the N-terminal region of human P2RX2. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | P2RX2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | P2RX2 (HGNC:15459) |
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Synonyms | P2X2 |
Function | ATP-gated nonselective transmembrane cation channel permeable to potassium, sodium and calcium (PubMed:10570044, PubMed:31636190). Activation by extracellular ATP induces a variety of cellular responses, such as excitatory postsynaptic responses in sensory neurons, neuromuscular junctions (NMJ) formation, hearing, perception of taste and peristalsis (By similarity). In the inner ear, regulates sound transduction and auditory neurotransmission, outer hair cell electromotility, inner ear gap junctions, and K(+) recycling (PubMed:23345450). Mediates synaptic transmission between neurons and from neurons to smooth muscle (By similarity). |
Cellular Location | Cell membrane; Multi-pass membrane protein {ECO:0000250|UniProtKB:P56373}. Note=Localizes to the apical membranes of hair cells in the organ of Corti. |
Tissue Location | Expressed in both the central and peripheral nervous system, as well as in the pituitary gland |
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Provided below are standard protocols that you may find useful for product applications.
Background
The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Six transcript variants encoding six distinct isoforms have been identified for this gene.
References
Allsopp, R.C., et al. J. Biol. Chem. 285(43):32770-32777(2010)
Decker, D.A., et al. Neurogastroenterol. Motil. 22(8):901-908(2010)
Coddou, C., et al. J. Neurosci. 29(39):12284-12291(2009)
Pannek, J., et al. Spinal Cord 47(7):561-564(2009)
Chaumont, S., et al. Sci Signal 1 (41), RA8 (2008) :
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