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TCEB2 Antibody (N-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - TCEB2 Antibody (N-term) AP16007A
    TCEB2 Antibody (N-term) (Cat. #AP16007a) western blot analysis in mouse brain tissue lysates (35ug/lane).This demonstrates the TCEB2 antibody detected the TCEB2 protein (arrow).
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q15370
Other Accession P62870, P62869, NP_009039.1
Reactivity Mouse
Predicted Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 13133 Da
Antigen Region 2-29 aa
Additional Information
Gene ID 6923
Other Names Transcription elongation factor B polypeptide 2, Elongin 18 kDa subunit, Elongin-B, EloB, RNA polymerase II transcription factor SIII subunit B, SIII p18, TCEB2
Target/Specificity This TCEB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 2-29 amino acids from the N-terminal region of human TCEB2.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTCEB2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ELOB (HGNC:11619)
Synonyms TCEB2
Function SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex) (PubMed:7638163). In embryonic stem cells, the elongin BC complex is recruited by EPOP to Polycomb group (PcG) target genes in order generate genomic region that display both active and repressive chromatin properties, an important feature of pluripotent stem cells (By similarity).
Cellular Location Nucleus.
Research Areas
Citations (0)
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Background

This gene encodes the protein elongin B, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. Pseudogenes have been identified on chromosomes 11 and 13.

References

Marcsisin, S.R., et al. J. Mol. Biol. 402(5):892-904(2010)
Piessevaux, J., et al. J. Biol. Chem. 283(31):21334-21346(2008)
Van Herreweghe, E., et al. EMBO J. 26(15):3570-3580(2007)
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
Bullock, A.N., et al. Proc. Natl. Acad. Sci. U.S.A. 103(20):7637-7642(2006)

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$ 182.50
$ 70.00
Cat# AP16007A
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