LASP1 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q14847 |
Other Accession | NP_006139.1 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 29717 Da |
Antigen Region | 120-148 aa |
Gene ID | 3927 |
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Other Names | LIM and SH3 domain protein 1, LASP-1, Metastatic lymph node gene 50 protein, MLN 50, LASP1, MLN50 |
Target/Specificity | This LASP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 120-148 amino acids from the Central region of human LASP1. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | LASP1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | LASP1 |
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Synonyms | MLN50 |
Function | Plays an important role in the regulation of dynamic actin- based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types (By similarity). |
Cellular Location | Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Note=Associated with the F-actin rich cortical cytoskeleton. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of a LIM protein subfamily characterized by a LIM motif and a domain of Src homology region 3. The encoded protein functions as an actin-binding protein and possibly in cytoskeletal organization.
References
Traenka, C., et al. Cancer Res. 70(20):8003-8014(2010)
Zhao, L., et al. FEBS J. 277(20):4195-4204(2010)
Zhao, L., et al. Gut 59(9):1226-1235(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Frietsch, J.J., et al. Br. J. Cancer 102(11):1645-1653(2010)
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