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IHH Antibody (N-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - IHH Antibody (N-term) AP14935a
    IHH Antibody (N-term) (Cat. #AP14935a) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the IHH antibody detected the IHH protein (arrow).
    detail
  • IHC-P - IHH Antibody (N-term) AP14935a
    IHH Antibody (N-term) (AP14935a)immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of IHH Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
IHC-P, WB, E
Primary Accession Q14623
Other Accession P97812, NP_002172.2, Q80XI9
Reactivity Human
Predicted Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 45251 Da
Antigen Region 51-80 aa
Additional Information
Gene ID 3549
Other Names Indian hedgehog protein, IHH, HHG-2, Indian hedgehog protein N-product, Indian hedgehog protein C-product, IHH
Target/Specificity This IHH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 51-80 amino acids from the N-terminal region of human IHH.
Dilution WB~~1:1000
IHC-P~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsIHH Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name IHH (HGNC:5956)
Function [Indian hedgehog protein]: The C-terminal part of the indian hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts followed by the covalent attachment of a cholesterol moiety to the C- terminal of the newly generated N-product (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Plays a role in hedgehog paracrine signaling (PubMed:24342078). Associated with the very-low-density lipoprotein (VLDL) particles to function as a circulating morphogen for endothelial cell integrity maintenance (PubMed:20839884).
Cellular Location [Indian hedgehog protein N-product]: Cell membrane; Lipid-anchor {ECO:0000250|UniProtKB:Q62226}. Note=The N-product remains associated with the cell surface. {ECO:0000250|UniProtKB:Q15465}
Tissue Location Expressed in embryonic lung, and in adult kidney and liver
Research Areas
Citations (0)
citation

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Background

This gene encodes a member of the hedgehog family of secreted signaling molecules. Hedgehog proteins are essential regulators of a variety of developmental processes including growth, patterning and morphogenesis. The encoded protein specifically plays a role in bone growth an differentiation. Mutations in this gene are the cause of brachydactyly type A1 which is characterized by shortening or malformation of the phalanges. Mutations in this gene are also the cause of acrocapitofemoral dysplasia.

References

Meulenbelt, I., et al. Ann. Rheum. Dis. (2010) In press :
Kang, S.J., et al. Hum. Mol. Genet. 19(13):2725-2738(2010)
Okada, Y., et al. Hum. Mol. Genet. 19(11):2303-2312(2010)
Zhao, J., et al. BMC Med. Genet. 11, 96 (2010) :
Chuang, P.T., et al. Nature 397(6720):617-621(1999)

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$ 182.50
$ 70.00
Cat# AP14935a
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