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TGIF2 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P-Leica, WB, E |
|---|---|
| Primary Accession | Q9GZN2 |
| Other Accession | NP_068581.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 25878 Da |
| Antigen Region | 171-199 aa |
| Gene ID | 60436 |
|---|---|
| Other Names | Homeobox protein TGIF2, 5'-TG-3'-interacting factor 2, TGF-beta-induced transcription factor 2, TGFB-induced factor 2, TGIF2 |
| Target/Specificity | This TGIF2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 171-199 amino acids from the C-terminal region of human TGIF2. |
| Dilution | WB~~1:1000 IHC-P-Leica~~1:500 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | TGIF2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TGIF2 |
|---|---|
| Function | Transcriptional repressor, which probably repress transcription by binding directly the 5'-CTGTCAA-3' DNA sequence or by interacting with TGF-beta activated SMAD proteins. Probably represses transcription via the recruitment of histone deacetylase proteins. |
| Cellular Location | Nucleus. Note=Excluded from nucleoli. |
| Tissue Location | Widely expressed. Highly expressed in heart, kidney and testis. Weakly expressed in brain and prostate |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a DNA-binding homeobox protein and a transcriptional repressor. The encoded protein appears to repress transcription by recruiting histone deacetylases to TGF beta-responsive genes. This gene is amplified and overexpressed in some ovarian cancers, and mutations in this gene can cause holoprosencephaly.
References
Watanabe, T., et al. Jpn. J. Cancer Res. 93(10):1114-1122(2002)
Deloukas, P., et al. Nature 414(6866):865-871(2001)
Melhuish, T.A., et al. J. Biol. Chem. 276(34):32109-32114(2001)
Imoto, I., et al. Biochem. Biophys. Res. Commun. 276(1):264-270(2000)
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