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IMPDH1 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, WB, E |
|---|---|
| Primary Accession | P20839 |
| Other Accession | D3ZLZ7, P50096, Q6GMG5, A0JNA3, NP_001136045.1, NP_899066.1, NP_001096075.1 |
| Reactivity | Human |
| Predicted | Bovine, Zebrafish, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 55406 Da |
| Antigen Region | 84-113 aa |
| Gene ID | 3614 |
|---|---|
| Other Names | Inosine-5'-monophosphate dehydrogenase 1 {ECO:0000255|HAMAP-Rule:MF_03156}, IMP dehydrogenase 1 {ECO:0000255|HAMAP-Rule:MF_03156}, IMPD 1 {ECO:0000255|HAMAP-Rule:MF_03156}, IMPDH 1 {ECO:0000255|HAMAP-Rule:MF_03156}, 111205 {ECO:0000255|HAMAP-Rule:MF_03156}, IMPDH-I, IMPDH1 {ECO:0000255|HAMAP-Rule:MF_03156}, IMPD1 |
| Target/Specificity | This IMPDH1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 84-113 amino acids from the N-terminal region of human IMPDH1. |
| Dilution | WB~~1:1000 IHC-P~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | IMPDH1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | IMPDH1 {ECO:0000255|HAMAP-Rule:MF_03156} |
|---|---|
| Synonyms | IMPD1 |
| Function | Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. |
| Cellular Location | Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03156, ECO:0000269|PubMed:14766016}. Nucleus {ECO:0000255|HAMAP-Rule:MF_03156, ECO:0000269|PubMed:14766016} |
| Tissue Location | IMP type I is the main species in normal leukocytes and type II predominates over type I in the tumor |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene acts as a homotetramer to regulate cell growth. The encoded protein is an enzyme that catalyzes the synthesis of xanthine monophosphate (XMP) from inosine-5'-monophosphate (IMP). This is the rate-limiting step in the de novo synthesis of guanine nucleotides. Defects in this gene are a cause of retinitis pigmentosa type 10 (RP10). Several transcript variants encoding different isoforms have been found for this gene.
References
Ohmann, E.L., et al. Pediatr Transplant 14(7):891-895(2010)
Gensburger, O., et al. Pharmacogenet. Genomics 20(9):537-543(2010)
Kagaya, H., et al. Basic Clin. Pharmacol. Toxicol. 107(2):631-636(2010)
Ohmann, E.L., et al. J. Heart Lung Transplant. 29(5):509-516(2010)
Shumei, L., et al. Adv. Exp. Med. Biol. 664, 293-297 (2010) :
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