Latexin Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P, FC, WB, E |
---|---|
Primary Accession | Q9BS40 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 25750 Da |
Antigen Region | 78-107 aa |
Gene ID | 56925 |
---|---|
Other Names | Latexin, Endogenous carboxypeptidase inhibitor, ECI, Protein MUM, Tissue carboxypeptidase inhibitor, TCI, LXN |
Target/Specificity | This Latexin antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 78-107 amino acids from the Central region of human Latexin. |
Dilution | WB~~1:1000 IHC-P~~1:10~50 FC~~1:10~50 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | Latexin Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | LXN |
---|---|
Function | Hardly reversible, non-competitive, and potent inhibitor of CPA1, CPA2 and CPA4. May play a role in inflammation. |
Cellular Location | Cytoplasm. |
Tissue Location | Highly expressed in heart, prostate, ovary, kidney, pancreas, and colon, moderate or low in other tissues including brain |
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Provided below are standard protocols that you may find useful for product applications.
Background
Latexin possesses nearly irreversible, non-competitive and potent inhibition of zinc-dependent metallocarboxypeptidases CPA1, CPA2, and CPA4. It is expressed in a neuronal subset in the cerebral cortex and cells in other neural and non-neural tissues of rat. Latexin plays a role in regional specification and/or morphogenesis of the forebrain.
References
Pallares,I., Proc. Natl. Acad. Sci. U.S.A. 102 (11), 3978-3983 (2005)
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