Mouse Map3k1 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, E |
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Primary Accession | P53349 |
Other Accession | Q13233 |
Reactivity | Mouse |
Predicted | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 161289 Da |
Antigen Region | 1194-1221 aa |
Other Names | Mitogen-activated protein kinase kinase kinase 1, MAPK/ERK kinase kinase 1, MEK kinase 1, MEKK 1, Map3k1, Mekk, Mekk1 |
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Target/Specificity | This Mouse Map3k1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1194-1221 amino acids from the C-terminal region of mouse Map3k1. |
Dilution | WB~~1:1000 IHC-P~~1:10~50 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | Mouse Map3k1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | Map3k1 |
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Synonyms | Mekk, Mekk1 |
Function | Component of a protein kinase signal transduction cascade (PubMed:14500727). Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4 (PubMed:14500727). May phosphorylate the MAPK8/JNK1 kinase (PubMed:17761173). Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway (PubMed:14500727). |
Tissue Location | Highly expressed in the heart and spleen while a lower level expression is seen in the liver |
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Provided below are standard protocols that you may find useful for product applications.
Background
Component of a protein kinase signal transduction cascade. Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4. Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway.
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