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AATK Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q6ZMQ8 |
| Other Accession | NP_001073864.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 144569 Da |
| Antigen Region | 46-74 aa |
| Gene ID | 9625 |
|---|---|
| Other Names | Serine/threonine-protein kinase LMTK1, Apoptosis-associated tyrosine kinase, AATYK, Brain apoptosis-associated tyrosine kinase, CDK5-binding protein, Lemur tyrosine kinase 1, p35-binding protein, p35BP, AATK, AATYK, KIAA0641, LMR1, LMTK1 |
| Target/Specificity | This AATK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 46-74 amino acids from the N-terminal region of human AATK. |
| Dilution | WB~~1:2000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | AATK Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | AATK |
|---|---|
| Synonyms | AATYK, KIAA0641, LMR1, LMTK1 |
| Function | May be involved in neuronal differentiation. |
| Cellular Location | Membrane; Single-pass type I membrane protein. Cytoplasm. Cytoplasm, perinuclear region. Note=Predominantly perinuclear |
| Tissue Location | Expressed in brain.. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene contains a tyrosine kinase domain at the N-terminus and a proline-rich domain at the C-terminus. This gene is induced during apoptosis, and expression of this gene may be a necessary pre-requisite for the induction of growth arrest and/or apoptosis of myeloid precursor cells. This gene has been shown to produce neuronal differentiation in a neuroblastoma cell line.
References
Tomomura, M., et al. Neuroscience 148(2):510-521(2007)
Lee, S., et al. Oncol. Rep. 16(4):747-754(2006)
Honma, N., et al. Biochem. Biophys. Res. Commun. 310(2):398-404(2003)
Tomomura, M., et al. Brain Res. Mol. Brain Res. 112 (1-2), 103-112 (2003) :
Tomomura, M., et al. Oncogene 20(9):1022-1032(2001)
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