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PTGIR Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, WB, E |
|---|---|
| Primary Accession | P43119 |
| Other Accession | NP_000951.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 40956 Da |
| Antigen Region | 210-238 aa |
| Gene ID | 5739 |
|---|---|
| Other Names | Prostacyclin receptor, Prostaglandin I2 receptor, PGI receptor, PGI2 receptor, Prostanoid IP receptor, PTGIR, PRIPR |
| Target/Specificity | This PTGIR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 210-238 amino acids from the Central region of human PTGIR. |
| Dilution | WB~~1:1000 IHC-P~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PTGIR Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PTGIR |
|---|---|
| Synonyms | PRIPR |
| Function | Receptor for prostacyclin (prostaglandin I2 or PGI2). The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase. |
| Cellular Location | Cell membrane; Multi-pass membrane protein. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a member of the G-protein coupled receptor family 1 and has been shown to be a receptor for prostacyclin. Prostacyclin, the major product of cyclooxygenase in macrovascular endothelium, elicits a potent vasodilation and inhibition of platelet aggregation through binding to this receptor.
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Ibrahim, S., et al. Arterioscler. Thromb. Vasc. Biol. 30(9):1802-1809(2010)
Reid, H.M., et al. J. Biol. Chem. 285(24):18709-18726(2010)
Muto, A., et al. Int Angiol 29 (2 SUPPL), 43-48 (2010) :
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
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